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  54. at least one of R and R can comprise a chemotherapeutic moiety; the other of R and R can be selected from hydrogen, halogen, N R, N O R, N OR R, NO, NO, N R S O R, N R S O R, N R C O R, N R C O OR, N R C O N R, CN, COOR, CON R, OH, SH, C alkylsulfanyl, C alkylsulfinyl, C alkylsulfonyl, S O N R, S O N R, C fluoroalkyl, C fluoroalkoxy, C alkyl, substituted C alkyl, C alkoxy, substituted C alkoxy, C cycloalkyl, substituted C cycloalkyl, C cycloalkyloxy, substituted C cycloalkyloxy, C cycloalkylalkyl, substituted C cycloalkylalkyl, C aryl, substituted C aryl, C arylalkyl, substituted C arylalkyl, C heteroalkyl, substituted C heteroalkyl, C heteroalkoxy, substituted C heteroalkoxy, C heterocycloalkyl, substituted C heterocycloalkyl, C heterocycloalkylalkyl, substituted C heterocycloalkylalkyl, C heteroaryl, substituted C heteroaryl, C heteroarylalkyl, and substituted C heteroarylalkyl; each of R, R, and R can be independently selected from hydrogen, deuterio, halogen, OH, N R, NO, NO, CN, COOR, CON R, C alkylsulfanyl, C alkylsulfinyl, C alkylsulfonyl, C alkyl, substituted C alkyl, C cycloalkyl, substituted C cycloalkyl, C heteroalkyl, substituted C heteroalkyl, C alkoxy, substituted C alkoxy, C heteroalkoxy, substituted C heteroalkoxy, C cycloalkylalkyl, and C cycloalkylheteroalkyl; R can be selected from a carboxylic acid COOH, a carboxylic acid analog, a carboxylic acid bio isostere, hydroxamic acids CONR OH, boronic acids B OH OR, phosphinic acids or derivatives thereof PO OH R, and phosphonic acid or derivatives thereof PO OH OR, sulfinic acid SOOH, sulfonic acid SO OH, sulfonamide SO NHR or NHSO R, sulfonimide or acyl sulfonimide SO NHCOR or CONHSO R, sulfonylureas SO NHCONHR or NHCONHSO R, amide CONHR or NHCOR, acylcyanamide CONHCN, 2, 2, 2 trifluoroethan 1 ols CH CF OH, 2, 2, 2 trifluoromethyl ketones and hydrates thereof COCF and C OH CF, acidic heterocycles and annular tautomers of any of the foregoing, and acidic oxocarbocycles or cyclic polyones and resonance forms of any of the foregoing; wherein R is selected from hydrogen, C alkyl, C fluoroalkyl, C cycloalkyl, and C aryl; each R can be independently selected from hydrogen, deuterio, halogen, hydroxyl, C alkyl, C cycloalkyl, benzyl, and phenyl; or two R together with the carbon to which they are bonded form a ring selected from a C cycloalkyl ring and a C heterocycloalkyl ring; R can be selected from hydrogen, deuterio, C alkyl, substituted C alkyl, C heteroalkyl, substituted C heteroalkyl, C alkoxy, substituted C alkoxy, C heteroalkoxy, substituted C heteroalkoxy, C cycloalkyl, substituted C cycloalkyl, C cycloalkyloxy, substituted C cycloalkyloxy, COOR, C fluoroalkyl, C fluoroalkoxy, C cycloalkyl, and phenyl; each R can be independently selected from hydrogen, deuterio, C alkyl and C alkoxy, or two geminal R together with the nitrogen to which they are bonded form a 3 to 6 membered heterocyclic ring; and L can be X в‚ђ, wherein, each X can be independently selected from a bond, C R, wherein each R can be independently selected from hydrogen, deuterio, halogen, hydroxyl, C alkyl and C alkoxy, or two R together with the carbon to which they are bonded form a C cycloalkyl ring or a C heterocycloalkyl ring, O, S, SO, SO, CO, and N R, wherein, R can be selected from hydrogen and C alkyl; and a can be selected from 0, 1, 2, 3, and 4 is there a generic viagra DNA methylation is the most characterized epigenetic mechanism of regulation of transcription

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